People experiencing persistent heartburn that lasts for hours and does not respond to medication are being advised to consult their doctor about a possible case of Mast Cell Activation Syndrome (MCAS). NHS GP Dr Asif Ahmed, who shares health advice on TikTok and Instagram, highlighted that the condition is often overlooked and can cause symptoms that mimic acid reflux.
Dr Ahmed explained that typical heartburn or reflux should not last all day, but some patients report symptoms persisting for over 12 hours. He noted that standard treatments such as lansoprazole or omeprazole may not be effective in these cases, prompting the need to investigate MCAS. The syndrome involves the inappropriate release of histamines, leading to allergy-like reactions without a clear trigger.
MCAS is increasingly recognised in the UK and can present with a range of seemingly unrelated symptoms, including fatigue, skin rashes, and digestive issues. In severe cases, it may cause anaphylaxis, a life-threatening allergic reaction. Dr Ahmed also pointed out that people with conditions like Ehlers-Danlos syndrome or hypermobility are more prone to MCAS-related heartburn.
Diagnosis typically requires a specialist, such as an immunologist or allergist. While there is no cure, management focuses on avoiding triggers, stabilising mast cells, and using antihistamines. Lifestyle changes, including a low-histamine diet with fresh foods, may also help. Patients are encouraged to keep a diary of potential triggers to aid in treatment.
