Creatine, a naturally occurring compound found in red meat and seafood and produced by the body, has become one of the most popular supplements for enhancing muscle size and performance. While research on creatine dates back to the 1830s, its use has expanded beyond bodybuilders to include clinical applications and benefits beyond muscle performance.
How Creatine Works
Once ingested, most creatine is stored in muscles as phosphocreatine (PCr). This form helps maintain energy levels by supporting adenosine triphosphate (ATP), the body's primary energy currency. By increasing intramuscular creatine levels, supplementation allows for higher intensity and longer duration resistance training, leading to greater gains.
Creatine's benefits extend beyond muscle performance. Research indicates positive effects on glucose storage and metabolism, blood flow dynamics, anti-inflammatory responses, and cognitive function.
Dosage and Safety
Typical dosage recommendations are five grams daily or 0.1 grams per kilogram of body weight. To obtain five grams from food alone, one would need to consume about 1.15 kilograms of beef or one kilogram of pork, making supplementation practical and cost-effective at approximately $0.50 per serving.
The International Society of Sports Nutrition states that creatine supplementation poses no greater adverse effects in healthy individuals compared to placebo, even at higher doses. Common myths about water retention, hair loss, and dehydration have been largely debunked by research.
Resistance Training Is Key
While creatine alone may offer some benefits, its effects are maximized when combined with resistance training. This combination enhances muscle growth, power, strength, and endurance. However, creatine is not essential; a healthy lifestyle with quality nutrition, adequate sleep, and stress management can also yield improvements.
Creatine remains a well-researched, widely accepted supplement with a safe profile and low cost, making it a practical choice for those seeking muscle growth and overall health benefits.
Scott Mills is a PhD Candidate in Kinesiology and Health Studies at the University of Regina. This article is republished from The Conversation under a Creative Commons license.



