A seismic shift is underway in Hollywood, where the once-celebrated curves and fuller figures of body-positive icons are being reshaped by a new wave of medical weight-loss solutions. The revolution is being fuelled by GLP-1 agonist drugs like Ozempic, Wegovy, and Mounjaro, with almost every month heralding a new 'suddenly slim' celebrity reveal that sends social media into a spin.
The Stars Embracing Medical Weight Loss
What makes this trend particularly headline-grabbing is the number of high-profile figures, long associated with championing self-love and body acceptance, who are now showcasing dramatic physical transformations. Icons including Amy Schumer, Lizzo, Meghan Trainor, Kathy Bates, and Oprah Winfrey have all undergone notable weight loss, often crediting or being linked to these pharmaceutical aids. Their journeys are turning heads and raising complex questions about beauty ideals in Tinseltown.
Amy Schumer, 44, a comedian renowned for rejecting retouching and joking about her curves in projects like I Feel Pretty, recently stunned fans by deleting old Instagram photos. She posted new images highlighting a slimmer figure, later crediting the GLP-1 drug Mounjaro for helping her lose roughly 40 pounds. Schumer has been brutally honest about Hollywood's secretive culture, stating, "Everyone's like, 'smaller portions.' Shut the f*** up. You're on Ozempic or one of those things."
Singer Meghan Trainor, 31, who rose to fame with the body-positive anthem All About That Bass, revealed in March 2025 that Mounjaro was part of her wellness journey after having her second child. On her podcast, she explained that both friends and her doctor recommended the drug, emphasising her goal was health for her family, not just aesthetics.
Health, Wellness, and Hollywood Pressure
For many, the decision to use medication is framed as a health necessity rather than a purely cosmetic choice. Kathy Bates, who lost around 80 pounds through diet and exercise before shedding a further 20 with Ozempic, was diagnosed with type 2 diabetes in 2017. Media mogul Oprah Winfrey revealed in 2023 that a GLP-1 drug helped her lose nearly 50 pounds after decades of 'yo-yo dieting' and battling intrusive 'food noise'.
Rebel Wilson used Ozempic during her 2020 'year of health' to lose 80 pounds, combining it with intense exercise and diet changes. The Pitch Perfect star has been transparent about the challenges, including regaining some weight due to stress, and has discussed how her changing body impacted the roles she was offered.
Other notable transformations include:
- Whoopi Goldberg, 67, who turned to Mounjaro after reaching 300 pounds while filming in 2021.
- Kelly Clarkson, 43, who slimmed down with a prescription weight-loss drug (not Ozempic, she insists) while managing thyroid issues.
- Golnesa 'GG' Gharachedaghi from Shahs of Sunset, who dropped from 138 to 110 pounds after starting Ozempic in 2023.
The Body-Positivity Paradox and Industry Impact
This wave creates a fascinating paradox. Stars who built their brands on celebrating curves and rejecting narrow beauty standards are now navigating a landscape where medical assistance for weight loss is becoming normalised. Their openness challenges the stigma around using medication, yet also prompts debate about whether the 'new skinny' is simply replacing one rigid standard with another.
Not everyone is on board. Kelly Osbourne, 38, who lost 85 pounds postpartum, firmly denied using Ozempic, attributing her change to cutting sugar and carbs. Her stance highlights that natural transformations remain a point of pride for some.
Ultimately, Hollywood's 'skinny revolution' underscores a broader cultural moment where powerful tools for weight management are becoming accessible. The stories of these celebrities reflect a complex mix of personal health journeys, medical advancement, and the relentless pressure of an industry perpetually redefining its ideals.
