Readers Share Mixed Experiences of Ozempic and Mounjaro Side Effects
Our community has shared deeply mixed experiences regarding the use of GLP-1 drugs such as Ozempic and Mounjaro, with many warning of severe and sometimes debilitating side effects. Others, however, have stated that more manageable symptoms were a price worth paying for the significant health benefits these medications can offer.
Personal Accounts Highlight Varied Reactions
Reacting to an investigation into the hidden side effects of these drugs, commenters shared a wide range of personal experiences. The discussion repeatedly returned to issues such as nausea, vomiting, digestive problems, and longer-term complications. Several readers described becoming severely unwell after starting treatment, with symptoms so disruptive that they felt the drugs were not worth continuing.
While some readers acknowledged that side effects can be mild or temporary for many people, they emphasised that this should not overshadow the experiences of those who suffer serious reactions. A number also criticised doctors for being dismissive of symptoms or too quick to prescribe medication without adequate follow-up care.
Underlying Concerns About Weight Loss Pressure
Underlying the discussion was a palpable unease about the societal pressure to tolerate severe side effects in pursuit of weight loss. Several readers questioned whether being thinner is ever worth the significant physical cost, highlighting a broader debate about health priorities and medical ethics.
Here is a detailed look at what readers had to say:
Positive Outcomes and Maintenance
All I can do is report on personal knowledge
"I've read the posts and articles about the negative side effects here and elsewhere. All I can do is report on personal knowledge. I, my brother and niece all use Mounjaro and have for over a year. My brother for diabetes and weight loss; my niece and I solely for weight loss. All three of us have had great success. My brother and I had no side effects, and my niece vomited for about three days, then all good. I understand this is the more typical scenario, albeit my desire is not to flaunt our good fortune – I recognise the awfulness of any side effect or failed medical intervention. I have now reduced my Mounjaro from 15 weekly to 7.5, which has provided a happy maintenance dose for four months. I lost 7.5 st (21 st to 13.5 st) and am very happy."
"PS. I dropped too quickly initially and did lose muscle tone. To counter this, I am eating more protein and doing light resistance exercises." – David65
Weighing Benefits Against Severe Symptoms
There are more important things than being thin
"You should stop the drugs as soon as the side effects became so awful. There are more important things than being thin. I have lost over four stone on Mounjaro and have had some side effects, but these have stopped now. I'm lucky, but I definitely wouldn't have carried on if I'd been vomiting like that. But now I have a new life and am extremely happy – as are thousands of others." – apple60
It wasn't worth it
"I didn't get as sick as the women profiled, but I was sick in bed for three weeks after my first, supposedly low, dose. Vomiting, retching, unable to eat, headaches – all, so I lost ten pounds not from the drug, but from how sick it made me. It wasn't worth it." – Tex237
Broader Societal and Medical Criticisms
Body fascism
"Personally, I put this all down to a segment of society's body fascism, especially with doctors. I've not been on Ozempic myself, but it's honestly not something I would like to be put on, having suffered from eating too much thanks to Prednisone when I started having chronic pain issues. I'd lost about 20 kilos beforehand and immediately put the weight back on thanks to Prednisone, and it's been tough to shift since then. Even now, I'm still getting the weight issue constantly, which I get – don't get me wrong – but it's hard not to feel bitter." – LimSitu
The first users are essentially guinea pigs
"All new pharmaceutical products go through testing before being allowed out to the public. Unfortunately, one test is being conducted by the public, and that is the long-term effects. For any new product, the first users are essentially guinea pigs for long-term use. Just like those initial soft contact lens wearers are finding out their corneas are thinning and they may need a corneal transplant in the future. No drug is 'perfect', but often the good they do outweighs the negative impacts. And remember, big pharma are not charities – they report to shareholders, and that's the system we have, regrettably." – Red Dragon
Specific Side Effects and Doctor Dismissal
The sulphur burps are real
"I took Ozempic for a couple of years, then switched to Mounjaro about a year ago for type 2 diabetes. I can tell you first-hand that nausea and the sulphur burps are real. The sulphur burps are terrible and will show up for weeks at a time and then disappear just as quickly. The burping is constant. It has become a real issue for my family and at work. I've discussed it with my doctor and he is dismissive of it and prescribes acid pills, which have very little effect." – Tom229
Critiques of Medical Approaches and Testing
Food can be an addiction
"Food can be an addiction in the same way anything can be. Perhaps treating people's weight issues without considering their wellbeing is at fault. Modern medicine focuses on prescription drugs as a quick fix, to the detriment of older, tried and trusted treatments." – Stimpymo
They have not been tested in the elevated doses
"'Although these drugs have been on the market for more than 20 years, they have not been tested in the elevated doses we are now seeing used in Wegovy, Zepbound and Mounjaro.' I find this outrageous. I should think the drug companies and/or GPs prescribing these in the aforementioned damaging doses can be sued. Without adequate testing over a long period on a very large and diverse (ie global) cohort, are we to assume they have absolved themselves from any duty of care to their patients? Because they should not be allowed to do that." – Moo100
Alternative Perspectives on Weight Management
It is a trade-off
"Every drug has side effects. It is a trade-off. With regard to losing weight, just eat a little less and exercise a little more – and keep doing it. No meds needed." – Patrick
Some of the comments have been edited for this article for brevity and clarity. The ongoing conversation reflects a critical examination of the risks and rewards associated with these increasingly popular weight loss medications.
