A BBC expert has issued important guidance for individuals taking proton pump inhibitors (PPIs), such as Omeprazole and Lansoprazole. These medications are commonly prescribed to reduce stomach acid production, with studies indicating that up to one in seven Britons may currently be using them.
Understanding PPIs and Their Use
Proton pump inhibitors are widely used to treat heartburn and acid reflux. In addition to Omeprazole and Lansoprazole, other common PPIs include Esomeprazole, Pantoprazole, and Rabeprazole. Dr Alexander van Tulleken, known as Dr Xand, appeared on BBC Morning Live to address concerns about the long-term safety of these drugs.
Host Helen Skelton asked whether acid reflux medication is safe to take. Dr Xand explained that heartburn occurs when acid from the stomach rises into the oesophagus, causing a burning sensation. The stomach is protected by a thick mucus layer, but the oesophagus lacks this defence, making it vulnerable to damage. Persistent acid reflux can increase the risk of oesophageal cancer and cause significant discomfort.
Safety Profile of PPIs
Dr Xand emphasised that PPIs are extremely safe and widely used globally. Recent trials have shown a very small increased risk of gut infections, approximately 0.4 per cent. However, this risk is outweighed by the benefits, including preventing dangerous bleeds and reducing cancer risk. He stated, "The data says they are very, very safe drugs."
Advice for Stopping PPIs
Many people consider stopping PPIs, but Dr Xand cautioned against abrupt discontinuation. If you purchase PPIs over the counter, follow the label instructions. The NHS advises not taking Omeprazole for more than two weeks without a prescription. For prescription users, consulting a GP is essential before stopping.
Dr Xand explained that stopping suddenly can cause a rebound effect, where the stomach produces excess acid, worsening symptoms. He advised, "You want to talk to your doctor before stopping taking them."
In summary, PPIs are effective and generally safe, but users should seek medical advice before discontinuing use.
